Fundamentals of Corporate Finance 9e - 82683 Words

http://helpyoustudy.info Chapter 01 - Introduction to Corporate Finance Chapter 01 Introduction to Corporate Finance Answer Key Multiple Choice Questions 1. Which one of the following terms is defined as the management of a firm s long-term investments? A. working capital management B. financial allocation C. agency cost analysis D. capital budgeting E. capital structure Refer to section 1.1 AACSB: N/A Difficulty: Basic Learning Objective: 1-1 Section: 1.1 Topic: Capital budgeting 2. Which one of the following terms is defined as the mixture of a firm s debt and equity financing? A. working capital management B. cash management C. cost analysis D. capital budgeting E. capital structure Refer to section 1.1 AACSB: N/A†¦show more content†¦I, II, III, and IV Refer to section 1.1 AACSB: N/A Difficulty: Basic Learning Objective: 1-1 Section: 1.1 Topic: Financial management 1-24 http://helpyoustudy.info Chapter 01 - Introduction to Corporate Finance 11. Which one of the following functions should be the responsibility of the controller rather than the treasurer? A. daily cash deposit B. income tax returns C. equipment purchase analysis D. customer credit approval E. payment to a vendor Refer to section 1.1 AACSB: N/A Difficulty: Basic Learning Objective: 1-1 Section: 1.1 Topic: Financial management 12. The controller of a corporation generally reports directly to the: A. board of directors. B. chairman of the board. C. chief executive officer. D. president. E. vice president of finance. Refer to section 1.1 AACSB: N/A Difficulty: Basic Learning Objective: 1-1 Section: 1.1 Topic: Corporate structure 1-25 http://helpyoustudy.info Chapter 01 - Introduction to Corporate Finance 13. Which one of the following correctly defines the upward chain of command in a typical corporate organizational structure? A. The vice president of finance reports to the chairman of the board. B. The chief executive officer reports to president. C. 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The Truth behind the Foster Care System Essay - 2119 Words

As family structure changes children pay the biggest price. They may lose the luxury of a stable home or school to call their own, when parent are no longer in the picture either. This is an issue that is largely ignored by society and most importantly the government. Without the foster system, children would be left abandoned and forgotten by all. The foster system provides thousands of homes for foster children each year, with parents that can give them what they need. But, foster care in America is inadequate for all American foster children and needs to be improved. Improvements are critical in bettering American foster systems, these improvements include, creating programs, finding more stable homes, and starting mentoring programs†¦show more content†¦There is also a lack of foster parents as well, to take in children. As long as the number of foster parents does not increase, there could be up to six foster children in one home (â€Å"All Foster† 9). It should become one of the top priorities to find stable homes for foster children to avoid the overcrowding. A stable home for foster children is exceedingly critical but the health of foster children is fundamental as well. The health of children entering the foster system is very important, but not always stressed. When entering the foster care system some children enter with health issues, such as developmental and psychiatric disorders (All Foster par. 3). There could be many reasons why they enter with these health issues. One could be due to the abuse and neglect many children encounter while with biological parents (par. 3). While in the care of foster parents, the health of foster children can be neglected as well (par. 4). â€Å"Younger foster children do not receive adequate preventive health care while in placement, many significant problems go undetected, or, when diagnosed are not evaluated and treated,† stated U.S. General Accounting Office (par. 5). 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The Periodontal Ligament Health And Social Care Essay Free Essays

string(45) " dentine it can travel the piece of dentine\." The periodontic ligament has assorted maps, in peculiar tooth support and eruption, related to its structurally complex administration. This is shown through its extended development trusting on the timing of events such as dentine formation so that the cells of the dental follicle can distinguish into those cells required to bring forth the periodontic ligament. The organisation of these cells in the mature periodontic ligament is indispensable in giving the tissue structural unity every bit good as enabling it to be compressed, which is of import to let for orthodontic motion every bit good as in maps such as chew. We will write a custom essay sample on The Periodontal Ligament Health And Social Care Essay or any similar topic only for you Order Now The fibroblast can be seen to be peculiarly of import in bring forthing the collagen fibres indispensable for back uping the construction as a whole. The PDL is hence seen is a complex specialised conjunction tissue, with much that still remains unknown about it. 1. Introduction The periodontium are the tissues that environment and back up the dentition, dwelling of: the gum, periodontic ligament, cementum and alveolar bone. The periodontic ligament ( PDL ) is a specialised connective tissue formed of cells and fibers embedded in a land substance incorporating cells, blood vass and nervousnesss. It is located between the root cementum of the tooth and alveolar bone covering the socket wall ; the country it occupies is the periodontic infinite. The ligament is uninterrupted with connective tissue of the gum every bit good as the mush chamber. The PDL is of involvement due to its importance in organizing an fond regard between the tooth and alveolar bone, which means that disease, can distribute easy from the unwritten pit through the back uping constructions of the dentition ( via the PDL/periodontium ) . Figure 1 – The PDL is shown in blue ( Nagal et al 2008 ) . 2. Function Tooth support mechanism The PDL is a robust tissue fond regard between the tooth and alveolar bone. It acts as a daze absorber to defy any occlusal forces and masticatory tonss, whilst protecting underlying tissues such as the root vertex. There are three chief constructions commanding tooth support: collagen fibers, land substance and vasculature. Experiments carried out by Kawada, Komatsu et Al ( 2000 ) on rat molar dentition show that collagen fibers can bear a high mechanical burden Fibres attach to the cementum of the tooth on one side and to the alveolar bone on the other side. They have a wavy orientation or ‘crimp ‘ due to cross-linking of the proteoglycans ( Gathercole, Keller et Al, 1983 ) . In burden, fibres uncrimp so stretch. It is suggested folds are involved in the initial phases of burden, leting some motion before the tissue is placed under tenseness. Fibroblasts are parallel to the collagen fibers. They attach to collagen via a fibronexus fond regard called plaque and can orientate the extracellular matrix ( Harris, Stopak, Wild et Al, 1981 ) . Fibroblasts are indispensable in tooth support due to their high rate of collagen turnover ; if they are damaged there is a rapid loss of back uping tissue of the tooth. Proteoglycans found in land substance lessening in molecular-weight fraction when tonss are applied. This is shown by an experiment carried out by Picton, Stanbury et Al ( 1987 ) on macae monkey dentition. There was a lessening in peak size of proteoglycans on application of tonss of 1N and a farther lessening in peak size by about 0.15 A280 unit with tonss of 4N. After a three hr recovery period there was an addition in molecular size of proteoglycans. It has been said the PDL is a suspensory ligament so the tonss are spread through oblique fibers running across the ligament to the alveolar bone. This theory relies on Hooke ‘s jurisprudence of elastic kick proposing if the tooth is pushed, it would react to the force proportionately. Therefore, the PDL responds elastically to coerce being applied. However, I do non believe this is feasible because of surveies carried out on nomadic dentitions by Parfitt et Al ( 1960 ) where a human upper jaw incisor was taken and the place of it measured at intervals before, during and after load application. The response produced a curving graph of burden against supplanting as shown in figure 2, whereas if the response was elastic a consecutive lined graph would be produced. This suggests that hysteresis is the likely method of tooth support as there is deficiency of supplanting with increased force because the system has memory. An experiment carried out by Moxham et Al ( 1989 ) on incisor dentitions of guinea hogs suggests dentitions exhibit a viscoelastic response to axial directed tonss. This is because the response of burden application is biphasic ; ab initio there is an elastic response followed by a slower, gradual response demoing a syrupy stage. Figure 2 – this graph is an axial load/mobility curve for a human upper jaw incisor to demo hysteresis. Consecutive tonss pass along different waies ( hysteresis cringles ) . ( Parfitt et al 1960 ) . The first stage demoing an elastic more additive response can be seen, every bit good as the 2nd more gradual syrupy stage. 2.2 Tooth eruption and impetus mechanisms For eruption to happen there must be a mechanism to bring forth the eruptive forces, processes where these forces are transferred to environing tissues enabling the tooth to be supported in place, so reconstructing of the periodontium to prolong the tooth. The periodontium is likely to be the beginning of the force for eruption. One position suggests that the force is produced by fibroblast contractibility whereas another position suggests that vascular hydrostatic force per unit areas are responsible. It has besides been proposed that a ‘zone of shear ‘ is a site of remodelling during eruption. Fibroblast contractility hypothesis Fibroblasts with smooth musculus cells such as ?-smooth musculus actin are called myofibroblasts. These make connexions with extracellular matrix through fibronexus. Myofibroblasts are thought to exercise tenseness on their extracellular matrix doing tooth eruption. When a fibroblast is placed in civilization with a piece of root dentine it can travel the piece of dentine. You read "The Periodontal Ligament Health And Social Care Essay" in category "Essay examples" Therefore it has been suggested contraction of fibroblasts in the development PDL is responsible for ‘pulling ‘ the tooth into the unwritten pit. Opposing grounds for this, such as an experiment carried out by the usage of lathyrogens ( drugs that inhibits collagen cross ) , in gnawer incisors showed that eruption was unaffected so collagen fibers are non required for eruption ( Berkovitz, Moxham, Newham et Al, 1995 ) . Vascular hydrostatic force per unit area hypothesis This hypothesis suggests that an eruptive force is generated by blood force per unit area act uponing the periodontic tissue hydrostatic force per unit areas. Position of dentitions can alter in synchronism with arterial pulsation ( movements up to 0.4um Berkovitz et Al ( 2008 ) and when arterial pulsation is zero, eruption does non happen farther back uping this hypothesis. Experimentally, utilizing hypotensive drugs there is an addition in eruptive motion due to an addition in periodontic hydrostatic force per unit areas. Stimulation of the sympathetic nervous system causes vasoconstriction therefore a reduced periodontic tissue force per unit area and decreased tooth eruption, but eruption starts once more one time the stimulation is removed. I think there is cogency in both hypotheses as tooth motion, whether it is eruption or impetus, could be caused by both of these. Although there is important grounds against the fibroblast hypothesis, it may still lend to tooth motion, but may non entirely be the cause of tooth eruption. 2. 3 Formation, care and fix of alveolar bone and cementum Cells are contained within the ligament in a reservoir and are available when needed for tissue homeostasis and repair/ regeneration. These are uniform mesenchymal cells which are produced to equilibrate out cells migrating out of the PDL or cells that dice. These cells include cementoblasts, cementoclasts, bone-forming cells and osteoclasts. Changes in forces involved in growing and impetus stimulate bone and cementum formation or reabsorption. Figure 3: Histological position of the Bone remodelling sequence ( Grigoriadis A, 2008 ) . Osteoblasts form bone whereas the osteoclasts resorb it. Extrinsic Sharpey fibers enter bone sheer from chief fibers of the PDL. Stem cells for bone-forming cells are found in the PDL. Osteoblasts are bone organizing cells that line the tooth socket, they synthesise collagen matrix and go enclosed in the matrix. They besides produce growing factors and may play a function in osteoclast map. Cementum is easy formed throughout life leting reattachment of PDL fibers, which are seen as a calcified portion of the cementum. Aceullar extrinsic fiber cementum as shown in figure 5 is derived from PDL Sharpey ‘s fibers that run into precementum. These are good mineralised extrinsic fibers and organize the matrix of cementum. 2. 4 Control of chew Sensory nervus fibers of the PDL are associated with mechanoreception via mechanoreceptors that have a low threshold and can be activated with tonss of 0.01 N ( Berkovitz et al, 2008 ) . Endings of mechanoreceptors are Ruffini-like and react proportionately to coerce applied. Mechanoreceptors are involved in masticatory and salivary physiological reactions. Sensory nerves from anterior dentitions convey information about contact between nutrient and the dentition, hence changing the force needed to pull strings the nutrient between dentitions. They modulate activity of the motor nerve cells of the nervus hypoglosus nervus involved in commanding the place of the lingua in chew. The PDL is involved in the jaw opening nonvoluntary physiological reaction which is triggered by mechanical or electrical stimulations being applied to unwritten mucous membrane, PDL or dentitions. A stronger stimulation produces a greater response. This is one theory that controls chew, another is that it is consciously controlled through instructions from the motor cerebral mantle. The beat generator theory suggests chew relies on cardinal spiel generators within the brain-stem. Fibroblast contractility is involved in chew as it allows for growing of the jaw. Their association with peculiar constituents of the matrix allows them to react to alterations in tenseness and compaction of extracellular matrix. Integrins are mechanostransducers that bind to extracellular matrix constituents to convey this stimulation to fibroblasts. Fibroblasts besides realign collagen filaments by drawing them back towards the cell. Fibroblasts and collagen fibers align parallel to the way of strain in the matrix. 3. DEVELOPMENT Overview The PDL signifiers after root formation begins. The internal and external epithelial tissue proliferate to organize Hertwig ‘s epithelial root sheath ( HERS ) . HERS fragments due to growing alterations and organize epithelial cell remainders of Malassez ( ERM ) . Now during tooth development, PDL formation begins ( in the cap phase ) . The enamel organ and HERS are surrounded by a dental pouch formed of condensed cells called the dental follicle. Cells of the dental follicle differentiate into cementoblasts, fibroblasts and bone-forming cells. Fibroblasts synthesise fibers and land substance of the PDL. Fibres become embedded in cementum ( formed by cementoblasts ) next to the dentine and in the bone laid down by the bone-forming cells at the other terminal. The PDL infinite is filled with an unorganized connective tissue between bone and cementum. This is remodeled by the extracellular matrix and is replaced by packages of fibers which become reorganized tissue, uninterrupted across the ligament infinite to procure fond regard of the tooth. This initial fond regard is modified after tooth eruption and one time occlusion establishes. 3.1 Embryonic Development The nervous tubing ( embryo ‘s precursor to the CNS ) develops via introversion of the exoderm into mesenchyme, following this nervous crest cells migrate to the dorsal midplane of nervous tubing and occupy the developing branchial arches Bronner-Fraser et Al ( 1995 ) . These ectomesenchymal cells when concentrated form the dental papilla and dental follicle Moxham et Al ( 1995 ) . Interactions between matrix adhesion molecules, syndecan and tenascin cut down migration and promote collection of ectomesenchymal cells promoting formation of the dental papilla and follicle Vainio, Thesleff et Al ( 1992 ) . The dental papilla is involved in formation of the tooth root including odontoblasts and dental mush. The dental follicle differentiates organizing the PDL cells every bit good as other cells of the periodontium, such as bone-forming cells and cementoblasts ( Yao, Pan, Wise et Al, 2008 ) . The dental follicle is seeable in the cap phase ( embryologic twenty-four hours 15 ) of development and signifiers from cranial nervous crest cells ( Chai et al, 2000 ) . It is required for eruption as it regulates osteoclastogenesis and osteogenesis ( Marks and Cahill et Al, 1984 ) ( Wise et al, 2005 ) . Evidence for development of the periodontium was proven by Nanci A et Al ( 1971 ) when tooth buds were labeled with tritiated thymidine and transplanted. Cementoblasts and fibroblasts in the development cell were labeled demoing that they originated from the transplanted tooth bud and as the dental follicle was merely transported with the tooth bud so it must be the beginning of primogenitor cells for the cementum, bone and fibroblasts. Work carried out by Palmer and Lumsden et Al ( 1987 ) confirmed this. Figure 4 shows the Cap phase of tooth development ( Cho and Garant at al 2000 ) This is the 2nd phase of development after the bud phase where the epithelial invaginates into the mesenchyme. At the cap phase the epithelial-mesenchymal interactions are still happening, but there is a greater difference between the cell types of the enamel organ. Centrally the cells are more rounded, whereas peripherally the cells are set uping themselves to organize the external and internal epithelial tissue. By late cap phase ( 12th hebdomad ) , the cardinal cells become detached merely keeping contact by desmosomes. This tissue is called the stellate Reticulum and develops further in the bell phase. The EEE remains cubelike whereas the IEE becomes columnar. The mesenchyme below the IEE is called the alveolar consonant papilla and that environing the tooth source is the dental follicle. Development of the PDL relies on the formation of root dentine and synthesis of cementum. As HERS encloses the dental papilla, distinction of odontoblasts is initiated from cells at the fringe of the dental papilla and formation of root dentine and atomization of the epithelial root sheath allows migration of dental follicle cells towards dentine and allows distinction into cementoblasts ( Cho and Garant et Al, 1988 ) . There are two chief cells types of the PDL ; mesenchymal cells of the dental follicle perifollicular mesenchymal cells Cells of the perifollicular mesenchyme are stellate-shaped, little, indiscriminately orientated, widely spaced. They have a little cytol incorporating unsmooth endoplasmic Reticulum, free ribosomes and long cytoplasmatic procedures to link with adjacent cells. As root formation progresses these cells addition in mutual opposition and man-made activity. They become extended with increased protein releasing cell organs enabling them to synthesize and lodge collagen filaments and glycoproteins in the development PDL ( Cho, Garant et Al, 1996 ) . 3.2 Development of the Fibres of the PDL Chief fibers of the PDL organize the chief part of the ligament and are found at the freshly formed root dentine, associated with fibroblasts. Collagen fibers are tightly packed by cementoblasts during development of noncellular extrinsic fiber cementum. In tooth eruption, fibers spread and merge across the breadth of the ligament to organize chief fibre packages. In the center of the ligament collagen fibers are less tightly packed. The bulk of chief fibers are coronal fibers running from the cementum to cram organizing the oblique fibers, which occupies two tierces of the ligament ( Grant, Berwich et al, 1972 ) . Agreement of oblique fibers allows for forces of chew to be absorbed. Histologically there are distinguishable fibre types shown in figure 7. As the root develops chief fibers become uninterrupted as Sharpey ‘s fibers in mineralised bone and noncellular cementum. Sharpey fibers are cemented into bone or cementum by a nonfibrillar matrix. Principal fibres develop earl ier in deciduous dentitions. All right brush-like fibers radiate from cementum, merely a few fibers project from the alveolar bone and widen into the unorganised collagenic cardinal zone. Sharpey fibers are thicker and more widely spaced than cementum fibers. They emerge from bone and widen towards the tooth, unknoting as they go. Cemented fibers still remain short. Alveolar fibers extend farther into the cardinal zone to fall in the length of the cemental fibers. With occlusal map, chief fibres become thicker and more uninterrupted ( Grant, Berwich et al, 1972 ) . 3.3 Development of the Cells of the PDL Tissues of the dental follicle in the developing root have three beds. Inner layer following to HERS. It is derived from the ectomesenchyme ( nervous crest beginning ) Outer bed next to the developing alveolar bone ( mesoblastic beginning ) Middle bed ( mesoblastic beginning ) Cells of the dental follicle give rise to cementoblasts, fibroblasts and bone-forming cells of the PDL. Fibroblasts are the chief cell type of the PDL and metabolize extracellular constituents. Osteoblast-like fibroblasts have besides been found incorporating alkalic phosphatase ( Lie, Yacobi, Savion, Narayan, Pitaru et Al, 1997 ) . These cells form bone cells and cementoblasts and bring forth aceullar extrinsic fiber cementum in the mature PDL ( Groeneveld, Everts et Al, 1995 ) . In eruption there may be alterations in non-fibrous extracellular matrix and the vascularity of PDL. Osteoclasts appear at the alveolar bone surface leting bone to reconstruct in association with tooth eruption and bone growing. Undifferentiated root cells are besides found as the PDL develops and once it is mature. These can distinguish into bone-forming cells, cementoblasts and fibroblasts. Research suggests these root cells are found in perivascular sites and in next endosteal infinites. They mature farther after migration into bone or cementum surfaces ( Mcculloch et al, 1993 ) . Further research needs to be carried out to find whether there is a common primogenitor cell for cementoblasts, fibroblasts and bone-forming cells. Some say cementoblasts arise from HERS every bit good as the dental follicle ( Zeichner-David et Al, 2003 ) others say that all of the cementoblasts arise from the dental follicle ( Diekwisch, 2001 ) . 3.4 Development of the Vasculature of the PDL Nerve fibers are seen in the mush, nevertheless few are found in the lower dental follicle that will organize the PDL. With root formation and eruption, nervousnesss adjacent to the bone grow into the PDL with blood. Centripetal excitation is established one time the ligament is to the full organised after eruption. Blood vass are derived from the periapical country from which they enter and pass upwards in the ligament. During eruption the tooth receives vass from the gum and capillaries of these dentitions may be extremely fenestrated.. 3.5 Molecular Mechanisms Development of the PDL is dependent on the extracellular matrix which regulates collagen filament formation ( McCulloch et al, 2000 ) . Small leucine rich proteoglycans such as lumican and decorin regulate administration of collagen filaments in development which was proven in decorin deficient mice by Matheson et Al ( 2005 ) . In contrast to this, Yamada et Al ( 2001, 2007 ) found that PDL-associated protein is specifically expressed in the dental follicle and mature PDL, which interacts with bone morphogenetic protein-2 to suppress the mineralisation of the PDL. Periostin is an adhesion protein which is expressed in the dental follicle, Rios et Al ( 2005 ) and Kia et Al ( 2006 ) suggest it is required for care of the PDL and is involved in the oncoming of periodontic disease. This is from research on periostin deficient mice demoing disorganized PDL and alveolar bone reabsorption.TGF?1/2 and BMP-4 are critical regulators in distinction of connective tissues such as the PDL ( Vainio et al, 1993 ) . 4. ANATOMY The PDL is the specialised connective tissue between the cementum covering the root of the tooth and the bone organizing the socket wall. It ranges in breadth from 0.15mm to 0.38mm Berkovitz et Al ( 2008 ) . The thinnest part is around the in-between tierce of the root which decreases in thickness with age. The mature PDL is subdivided into three parts ( Sloan, Carter et al, 1995 ) . – Bone-related part rich in cells and blood vass, – Cementum-related part with heavy well-ordered collagen packages – Center zone incorporating fewer cells and dilutant collagen filaments Dentine- side of PDL Bone- side of PDL Figure 5: Sharpey ‘s fibers extend into the dentine and alveolar bone on both sides. These are extensions of the chief fibers widening across the PDL infinite Fibroblasts Blood vass Extracellular Matrix ( I ) Collagen fibers Collagen is a quaternate protein formed of amino acids, glycine and proline, that coil into a ternary spiral to organize strong fibers found in connective tissues of ligaments and sinews. Collagen fibres consist of microfibrils composed of tropocollagen molecules. Collagen packages are found in the PDL embedded in an formless ( shapeless ) background stuff, land substance ( Nanci and Bosshardt et Al, 2006 ) . Hempen collagens The bulk of collagen is present as Type 1 and Type III hempen collagens in a ratio of 3:1 ( Berkovitz et al, 2008 ) . Approximately 70-80 % of PDL collagen is type 1 ( Wagle et al, 2005 ) .This is a major constituent of most connective tissues, such as tegument and bone. Type III collagen is found at the fringe of Sharpey ‘s fibers and close nervousnesss and blood vass, every bit good as high sums being found in immature developing tissues and in granulation tissue Berkovitz et Al ( 2004 ) . 15 % of collagen is found to be type III collagen of unknown map. However it is associated with sites of the organic structure with a rapid turnover and is found covalently linked to type I collagen throughout the PDL ( Berkovitz, Holland, Moxham, 1992 ) . Non -fibrous collagens Type V, VI, XII – Type VI collagen is absent from the center of the ligament during the eruptive stage, whereas Type XII collagen appears after eruption tardily in development. There may be increased Type V collagen in periodontic disease. Type IV, VII -these are basement membrane collagens of blood vass and epithelial cell remainders. Non -fibrous collagens act to keep hempen collagens in a 3-dimensional web. Evidence of this was seen in transgenic mice ( DNA from another being ) with a mutant of collagen type Twelve where there is a break of the agreement of collagen fibers ( Berkovitz, Holland Moxham et Al, 1992 ) . The diameter of collagen filaments is little, with a mean of 50 nanometer. There are no age-related alterations, but the diameter may alter with periodontic disease. A specialised characteristic of collagen in the PDL is its high rate of turnover which may be the fastest in anyplace in the organic structure, these characteristics are quantified in Figure 6. The turnover is non related to functional considerations ( Berkovitz et al, 2004 ) . Figure 6 – This qualitatively shows the specialised characteristics of the PDL compared to the gingival tissue ( Berkovitz et al 2004 ) . It can be seen that the turnover rate in the PDL is five times every bit fast as that in the gum, which is related to the increased sum of Type III collagen. Chief fibers These are about 5micron collagen fiber bundles that run across the PDL and infix into cementum and bone on each terminal. The alveolar crest group – attached to the cementum below the CEJ. They run downwards and outwards to infix into the air sac. The horizontal group – apical to the alveolar crest group. Run at right angles to the long axis of the tooth from the cementum to the bone. The oblique group – the most legion group. They run from the cementum sidelong to infix into bone coronally. The apical group – radiate from the cementum around the vertex of the root to the bone. They form the base of the socket The interradicular group – are found between the roots of multirooted dentitions. They run from the cementum into the bone organizing the crest of the interradicular septum. Figure 7 – Chief fibre groups of the PDL ( Nanci A EL Al Oral Histology P.266 ( 2003 ) ( A ) Transseptal, ( B ) Alveolar crest, ( C ) Horizontal, ( D ) Oblique ( Tocopherol ) Apical ( F ) Interradicular There is contention over the extent of the single fibers traversing the breadth of the PDL. Position 1 There are distinguishable tooth-related and bone-related fibers that intercalate near the center of the ligament as an intermediate rete. This rete explains how the forces of tooth eruption may be sustained However this may be an artifact related to collagen fibers in turning incisors looking as sheets instead than packages. Position 2 This is a more recent position proposing the fibers cross the full breadth of the periodontic infinite but subdivision en path and articulation neighbouring fibers to organize a complex 3-dimensional web. I think a complex web of fibers is more likely in the PDL due to the functional demands placed on it and for it to carry through its maps of tooth support and eruption. Sharpey ‘s Fibers The part of chief fibers embedded into bone or cementum are known as Sharpey ‘s fiber. In primary noncellular cementun fibers are to the full mineralised, nevertheless those in cellular cementum and bone are partly mineralised at their fringe. Sharpey ‘s fibers can infix uninterrupted into the bone of the alveolar procedure and continue as chief fibers of an next PDL fond regard. They have a complex construction and lace-like form and can widen buccally and linguistically with fibers of the periosteum. The gingival ligament is besides involved in keeping functional unity and is formed of groups found in the lamina propria of the gum. Figure 8- Sharpey ‘s fibers hypertext transfer protocol: //www.bu.edu/histology/p/10003loa.htm ( 28/02.10, 23.19 ) 4.1 ( two ) Oxytalan fibers These are pre-elastin fibers organizing about 3 % of all fibers of the PDL ( Berkovitz et al, 2004 ) . They are attached into the cementum of the tooth and cross out as a delicate web into the PDL. They are concentrated in the cervical part of the ligament where they run parallel to the gingival group of collagen fibers. In the chief portion of the PDL they are longitudinal and traverse the oblique fibres sheer. The oxytalan fibres terminate around blood vas. These fibers increase in figure and thickness in dentitions that carry abnormally high tonss such as abutment dentitions for Bridgess. They may hold some function in tooth support in relation to vasculature. Oxytalan microfibrils are similar in construction and map to fibronectin filaments. These are involved in adhesion and migration of fibroblasts. Due to their snap from the elastin fibers formed by fibroblasts, they are able to react to tenseness. Figure 9 – Oxytalan fibre hypertext transfer protocol: //www.dentistry.ucla.edu/PIC/members/force/index.html 28/02/10 23.22 ( A ) Cementum, ( B ) Principal oxytalan fiber ( C ) Oxytalan piece of land ( D ) Periodontal vas. 4.1 ( three ) Land Substance The PDL is composed of 60 % land substance by volume ( Berkovitz et al, 2004 ) dwelling of glycosaminogylcans, proteoglycans and glycoproteins secreted by fibroblasts. Hyaluran is a gylycosaminoglycan consisting a big volume of the land substance. It affects the permeableness and motility of the PDL tissue. The two chief proteoglycans are proteodermatan sulfate and a proteoglycan containing chondroitin sulphate/dermatan sulfate loanblends. Proteodermatan sulfate is related to decorin which increases the strength of collagen filaments. Land substance can besides change collagen orientation. Glycoproteins such as fibronectin are involved in cell migration, orientation and fond regard. Tenascin is another glycoprotein, besides found in the immature PDL. It is non found throughout the PDL like fibronectin, but is located in parts near alveolar bone and cementum. Employee turnover rate of land substance is greater than collagen and it is involved in ion and H2O binding every bit good as exchange of substances such as adhering growing factor. Tissue unstable force per unit area is high in the PDL at 10 millimeters Hg above atmospheric force per unit area, hence impacting tooth support and eruption mechanisms. Land substance inhibits mineralisation of the PDL. Experiments where enzymes that degrade the land substance, such as spreading factor and chondroitinase are applied to the PDL followed by mineralizing solution prove this, as mineral crystals appear. Calcium adhering proteins such as S100A4 in extracellular matrix besides prevent mineralisation ( Berkovitz et al, 2004 ) . In periodontic disease there is a lessening in dermatan sulfate and an addition in chondroitin sulfate. Remodeling of the PDL occurs in deficiency of occlusal operation, where there is a lessening in chondroitin sulfate, decorin and Lipo-Hepin sulfate. Changes in the land substance could measure the patterned advance of disease, such as in measuring the gingival crevicular fluid for these proteins. 4.2 Cells 4.2 ( I ) Fibroblasts Poundal fibroblasts are big cells with an extended cytol and many cell organs associated with protein synthesis and secretion- unsmooth endoplasmic Reticulum, Golgi composite, chondriosome and secretory cysts. This reflects their high rate of collagen and land substance synthesis. They have a developed cytoskeleton with adherens and spread junctions due to their functional function. Fibroblasts are aligned along the way the fiber packages are in and widen cytoplasmatic procedures that wrap around collagen packages. Collagen fibrils in packages are invariably being remodeled as fibroblasts are capable of both synthesising and degrading collagen. Evidence for this is seen in the presence of intracellular collagen profile within cells ( Chris everts, Zee, Creemers, Beertsen et Al, 1996 ) . The profiles contain collagen in changing visual aspects, from normal banded filaments to unbanded filaments. Cellular activities of fibroblasts are controlled by modulatory molecules such as growing factors and cytokines. IGFI, BMPs, PDGF, IL-1, TGF? stimulate synthesis of collagen and inhibit synthesis of metalloproteinases, for illustration collegenase. Tissue harm relates to an addition in cytokines to forestall debasement. Fibroblasts besides produce factors that inhibit osteoclastic distinction, such as osteoprotegerin which inhibits bone reabsorption. Alkaline phosphatase is an enzyme related to the formation of aceullar cementum found in fibroblasts. It has receptors to epidermal growing factor that inhibit the fibroblast from distinguishing into cementoblasts or bone-forming cells. Other molecules such as TGF? , IGFI, BMP-2, BMP-7 and FGF-2 regulate proliferation and distinction of fibroblasts, bone-forming cells and cementoblasts. Figure 10 – Conventional representation of a fibroblast hypertext transfer protocol: //www.tiho-hannover.de/einricht/anat/lit/mwenth/conntis 28/02/10 23.55 Poundal fibroblasts are able to degrade and synthesize collagen. Degradation occurs through phagocytic activity happening through the intraceullular collagen vacuoles in fibroblasts that ingest the collagen from the extracellular environment ( Berkovitz, Newham 1995 ) . Degradation involves acerb phosphatase and cathepsins. Synthesis of collagen occurs via the protein releasing organels round in the fibroblasts. Fibrils form via wadding of single tropocollagen molecules. Figure11 – Fibroblasts in cell civilization from a mouse embryo ( Todaro et al 1963 ) 4.2 ( two ) Bone and cementum cells These cells are situated within the PDL, but are involved in organizing difficult tissues. Cementoblasts These are cement organizing cells that line the surface of cementum. They are little and cubelike in form packed with cell organs involved in secernment. These cells become trapped in Howship ‘s blank one time the cementum has been laid down. Osteoblasts These are bone organizing cells that line the tooth socket. They are cubelike in form and have a secretory function. Cementoclasts and osteoclasts These reabsorb cementum and bone and originate from macrophage-derived cells. They sit in Howship ‘s blank where a coppice boundary line develops. Figure 12 demoing the basic construction of an Osteoclast ( Grigoriadis A, 2008 ) 4.2 ( three ) Defence cells Defence cells found in the PDL consist chiefly of mast cells and macrophages. Mast cells are found near to blood vass as they degranulate in hypersensitivity type 1 reaction. Eosinophils can besides be found. 4.2 ( four ) Epithelial remainders of Malassez Epithelial cells found in the PDL are leftovers of HERS. They are found nigh cementum as a bunch of cells that form an epithelial web. More of these cells are found in forking countries, at the vertex of deciduous dentitions and in the gum of older dentitions. They may hold a function in periodontic repair/regeneration as they can be stimulated to proliferate. 4.2 ( V ) Stem Cells and Precursors Undifferentiated mesenchymal cells are required due to changeless omission of cells by programmed cell death, which needs to be balanced by production of new cells in order to keep homeostasis. In lesion mending these cells differentiate to mend the ligament itself, but besides produce cells to reconstruct the lost bone and cementum ( Beersten, Van den Bos, Everts et Al, 1997 ) . They have a perivascular location and may besides be found in endosteal infinites of alveolar bone. Different stimuli recruit primogenitors bring forthing different cell types, such as bone-forming cells in orthodontic burden. Recently root cells found in the PDL have been isolated turn outing their presence ( Seo, Miura, Gronthos, Bartold, Batouli, Brahim, Young, Robey, Wang, Shi et Al, 2004 ) . 4.3 Vascularization 4.3 ( I ) Blood supply The PDL is highly vascularised. Major blood vass are postcapillary venulas that run between chief fiber packages and shut to alveolar bone. Fenestrated capillaries allow diffusion and filtration ; this may be connected to high tissue fluid force per unit area. The sum of fenestrations alterations harmonizing to the phase of eruption ( Berkovitz, Newham, Moxham et Al, 1995 ) . 4.3 ( two ) Nerve supply The PDL is associated with many sensory and autonomic nervousnesss. Centripetal nervousnesss are associated with nociception and mechanoreception ( chew ) , whereas autonomic nervus fibers are associated with supply of blood vass. Nerve bundles enter near the root vertex or through the center and cervical parts of the PDL as finer subdivisions through the alveolar bone. Fibers can be myelinated if they are centripetal nervus fibers, unmyelinated fibers can be both centripetal and autonomic. Sensory nervus terminations in the PDL besides release neuropeptides, for illustration substance P and vaso-active intestinal. These substances affect blood vass and are upregulated in redness and orthodontias. 5. Clinical Indication Periodonticss Periodontic diseases cause a loss of collagen fibroblasts. This is because in redness there is an addition of tissue inhibitors i.e. matrix metalloproteinases expressed that destroy collagen. TIMP ‘s can be found of course produced by PDL fibroblasts themselves. Periodontic disease could be controlled by suppressing matrix metalloproteinases, hence diminishing tissue devastation. Drugs such as Achromycin and Vibramycin act in this manner. At the initial phase of periodontic disease there is redness of the country, nevertheless due to the high turnover rate of the tissue, regeneration can happen. If there is a loss of fond regard there is no continuity with the gum leting more bacteriums to colonize pockets and hence disease progresses. Symptoms such as Mobile, floating dentitions that are prone to falling out in are seen in advanced periodontal disease. More type V collagen every bit good as a alteration in fibril diameter can be found in the PDL. 5.2 Orthodonticss The PDL regulates motion of dentitions under tonss and is involved in conveying mechanical forces to cram. The ligament shows viscoelasticity and hysteresis every bit explained in figure 2. After application of a force the tooth moves a short distance and so halt. This is because of little deformation of alveolar bone and compaction of PDL fibers. Alveolar bone will reabsorb preferentially over cementum and the tooth moves in the way of the force being applied Certain countries of the PDL are compressed and others are under tenseness and it is these alterations that result in bone remodelling and tooth motion. Remodeling involves dislocation of the matrix of the ligament that connects the bone and cementum. The 3D-meshwork of fibers adapt to emphasiss through realignment of the collagen fibers arranged in land substance Mechanical emphasiss produced by orthodontic contraptions, alter fractal dimension of the periodontic – bone interface. This is a step of the ability of an object to make full infinite, the more infinites it fills the greater the fractal dimension. The alteration is relative to the size of force applied. Fractal dimension was measured at the vertex of maxillary grinders to demo the response of mechanical burden ( Wagle, DO, Yu, Burke et Al ) . Decisions were that fractal dimension increased along the full root length connoting that these alterations are due to physical burden as opposed to a cellular response. This is one position point nevertheless others suggest both a physical and a cellular response of reconstructing. A cellular response means osteoblastic /osteoclastic activity, such as the osteoblastic instead than fibroblastic response following orthodontic loading- bone-forming cells respond to the force per unit area and reabsorb alveolar bone. Endodonticss Irritation of the PDL can happen in root canal intervention due to overextension of the file beyond the apical bottleneck during the process. This forces dust and fluid towards the periapical tissues, which can inflame. A periapical abscess can develop around the root vertexs of the septic tooth and do farther redness. Root canal sealants can be cytotoxic to the PDL fibroblasts and ‘Canals ‘ was the most toxic sealant as proven by an experiment carried out by Chang et Al ( 2010 ) . 6. Decision This undertaking was carried out to explicate the maps, development and anatomy of the PDL. The function of fibroblasts in peculiar I found is indispensable in all of these parametric quantities. This is due to them bring forthing the collagen fibres that history for keeping the structural unity of the tissue for tooth support every bit good as theories of fibroblast contractility in tooth eruption. Clinically the absence of the fibroblast in periodontias could finally take to exfoliation of dentitions. The mechanisms by which the alveolar consonant follicle differentiates into the cementoblasts, bone-forming cells and fibroblasts of the periodontium is relevant non merely to the PDL but to the periodontium in general. Developmentally, molecular mechanisms that modulate the activity of the cells come from the original PDL cells themselves, which contributes to functions of care, fix and regeneration. Although the importance of the construction of the PDL can be seen, there is still a batch that remains unknown such as the intent of the type III collagen fibers and why these are associated with the tissue have a high turnover rate, every bit good as the intent of oxytalan fibres. The relevancy of this connective tissue can be seen clinically in many different instances, hence holding a good apprehension of its construction has helped me appreciate the effects of, for illustration periodontic disease, on the PDL from a clinical point of position. How to cite The Periodontal Ligament Health And Social Care Essay, Essay examples

The Kill 30 Seconds to Mars Essay Example For Students

The Kill 30 Seconds to Mars Essay What would one expect to be the nature of a man who is cut off from society in an isolated hotel? I would say he slowly slips into insanity, which is precisely the outcome of the music video The Kill, ? performed by the alternative rock band, 30 Seconds to Mars. It was named as the greatest rock video of its time. The music video is an allusion to the classic horror film The Shining, ? based on a novel written by Stephen King. However, it is more than just a man falling into madness, it is about finding himself in the process. Both the horror film and the music video display recurring themes throughout literature: mental instability, finding oneself, and coping with a multiple personalities. One must conquer internal battles in order to allow personal identities to surface. The Shining, ? tells the tragedy of Jack Torrance and his family living in a remote hotel as the winter caretakers. Eventually the father, Jack, falls into madness attempting to kill his family. The music video The Kill ? follows the same concept, in which the group seeks complete isolation in an abandoned hotel, where their minds slowly drift into madness, mimicking the movie. While the music video and the movie are different, they have similarities. The not as obvious, but most parallel, would be the doubling effect. The music video presents a clearer picture of the doubling effect showing the band members coming face to face with a physical version of themselves, the real them. In The Shining, ? Jack faces an alter ego of himself, the dark and self-absorbed version. Jack does a good job hiding his nature, but as the madness hits full swing, Jacks real personality is displayed. In both, it is an internal confrontation amongst ones different personalities. While, in the movie, the personality he has been trying so hard to cover up has finally reached the surface, his personalities are working against each other creating a mad man. In the music video his multiple personalities work with each other. Both the sane version and the mad version are seen at the end of the video working together in unity. The imagery in the music video produces a sense of emotion and creates an atmosphere that appeals to the audience. Images such as the band members wearing all black indicates a tortured and tormented soul, along with the dark setting. The most dominate color throughout the entire video is black, creating an atmosphere of mystery and death. The different shades of grey present in the opening scene set the mood for the video, haunting. While images such as a dead woman appearing on the screen add a sense of horror to the video. The video was shot from the outside looking inward, invading the lives of the band members as they slowly go insane. The movements of the camera aid in the overall feel of the music video. The close-ups of the lead singer allows for one to look into his eyes and see the emotions and the effects of the madness that occur over time. The panning effect allows the viewer to see the story take place in the entire hotel. The use of sound effects plays an extensive role throughout the video. Several times the music comes to a pause; the lack of sound creates a frightening yet eerie atmosphere contributing to the overall sense of doubt. It is important to notice in the opening scene that no music is playing; the only sounds being heard are the words coming from a band members mouth. .u27b535c94fce1fb1b0b5e65e1962ef45 , .u27b535c94fce1fb1b0b5e65e1962ef45 .postImageUrl , .u27b535c94fce1fb1b0b5e65e1962ef45 .centered-text-area { min-height: 80px; position: relative; } .u27b535c94fce1fb1b0b5e65e1962ef45 , .u27b535c94fce1fb1b0b5e65e1962ef45:hover , .u27b535c94fce1fb1b0b5e65e1962ef45:visited , .u27b535c94fce1fb1b0b5e65e1962ef45:active { border:0!important; } .u27b535c94fce1fb1b0b5e65e1962ef45 .clearfix:after { content: ""; display: table; clear: both; } .u27b535c94fce1fb1b0b5e65e1962ef45 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u27b535c94fce1fb1b0b5e65e1962ef45:active , .u27b535c94fce1fb1b0b5e65e1962ef45:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u27b535c94fce1fb1b0b5e65e1962ef45 .centered-text-area { width: 100%; position: relative ; } .u27b535c94fce1fb1b0b5e65e1962ef45 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u27b535c94fce1fb1b0b5e65e1962ef45 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u27b535c94fce1fb1b0b5e65e1962ef45 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u27b535c94fce1fb1b0b5e65e1962ef45:hover .ctaButton { background-color: #34495E!important; } .u27b535c94fce1fb1b0b5e65e1962ef45 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u27b535c94fce1fb1b0b5e65e1962ef45 .u27b535c94fce1fb1b0b5e65e1962ef45-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u27b535c94fce1fb1b0b5e65e1962ef45:after { content: ""; display: block; clear: both; } READ: Song Summary: Hey Kid - If/Then EssayAs they enter into the hotel, a noise is heard, something that would appear in a horror film. This brief introduction shows the audience what will transpire as the video progresses. The music comes to a sudden stop, and brings back the horrific sounds from the opening scene. These sounds add to the creepiness and suspense that builds throughout the music video. It sends chills up the viewers spines whenever they hear the sounds, making them even more eager to see what is going to happen next. The lyrics play an intense role in the foundation of the music video. Listening to the song for the first time it appears to be a dialogue between two individuals, a male and a female. However, the song is a monologue of the main character seeking to find his true identity. The artist, Jared Leto, says it is about the relationship between yourself. It is about confronting the truth of who you are ? (Wikipedia. com), these words build the theme, aiding in its development. The phrase this is who I really am ? (line 24), ties the music video and the song together, working in conjunction of one other. The lead singer is seen face to face with his double in the hallway screaming these words to each other, Fighting for a chance, I know now this is who I really am ? (lines 26-27). He has found the real him, although unwilling to except it at first, he finally realizes this is who he is. All in all, the lyrics, images, and sounds combine to make for a gruesome but captivating video. The allusion to the classic film The Shining ? shows that ones true personality will eventually come to the surface. However, the entire music video relates to human beings, in a world where being different is frowned upon. People tend to put on a front in front of others, but behind closed doors is where ones true personality lies. Some people may not be as dramatic and sinister as the band members in the music video, but humans all struggle with finding out the real version of themselves. Ultimately, the song is about accepting ones identity, and one day people will eventually be able to scream this is who I really am. ? Bibliography: Leto, Jared. The Kill  . Lyrics. A Beautiful Lie. Universal Music Publishing Group.24 Jan, 2006 30 Seconds to Mars. The Kill  . Online video clip. Youtube, 22 Sept, 2010. Web. 11 Sept, 2014 https://www.youtube.com/watch?v=8yvGCAvOAfM Wikipedia. The Kill  . 30 Aug, 2014 Web. 11 Sept. 2014

The Meaning of Life free essay sample

I believe the meaning of life is to give life a meaning. Throughout my entire life, I have wondered what the purpose is. Why am I and every other human being even on this planet in the first place? That brings me to my next question. Is there a God? If there is, why did he put us here? Any Christian asked will say our sole purpose is to serve God. First of all, what does that even mean? And second, I must ask why? Why would a supernatural being place us strategically on this planet strictly to serve him? That sounds pretty selfish to me. There has to be something more. Something concrete. Something greater. How could there not be? All my life I have worked hard to succeed. I have challenged myself and fought to do better than my best. Why? I asked myself. Why stress so much when I’m only going to die in the end? Pessimistic, I know. We will write a custom essay sample on The Meaning of Life or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Finally, I thought, maybe the meaning of life doesn’t have to be so complex. Maybe the meaning of life is whatever we want it to be. Maybe the meaning of life is to give life a meaning. I do what I do because I want to do it. It’s that simple. I do it because it means something to me. Everyone adds their own meaning to life. The meaning of life is never universal. The meaning of life is never complex. The meaning of life is actually quite simple to think about. Many people help the needy. Others play sports. Both activities add meaning to those lives involved. Purposes change, but the overall meaning of life will always stay the same. The meaning of life is simply to give life a meaning. This I believe. The Meaning Of Life free essay sample â€Å"The Meaning of Life† is an excerpt from Richard Taylor’s book Good and Evil: A New Direction, with this book Mr. Taylor was thought to have adopted a radical subjectivist view of ethics. In this excerpt he explains why existence and life is meaningless and he sheds light into the meaning of life. Throughout his explanations Richard uses an example from an ancient Greek myth. The myth is about Sisyphus a Greek man who offended the gods and was sentenced to roll a large stone up a hill for all of eternity. We will write a custom essay sample on The Meaning of Life or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Richard starts his explanation of the â€Å"Meaningless of Existence† with the toils of Sisyphus. Sisyphus is forced to roll a stone up a hill, when it is near the top the stone will roll back down and he is forced to roll it up again, only to have it fall once more to be rolled up again and again for all of eternity. It is Sisyphus’ punishment that we will focus on. Sisyphus is the picture of a â€Å"meaningless, pointless toil of a meaningless existence that is absolutely never redeemed†(Taylor, Richard). He has lost all purpose in life except to roll a stone; it is a never ending nightmare that he will never awaken from. Taylor gives other examples of meaningless tasks, a relay styles race with a precious gem transported back and forth in a never ending cycle, and a digging hole only to be refilled with the same earth. The points to all this is that all these tasks are pointless and without meaning. The story could be different and Sisyphus can have meaning if he circumstance were different, if Sisyphus rolled stone to the top and all the stone accumulated into a wonderful and enduring temple, he would have some meaning to his labors. If the gods as an after thought made it so that Sisyphus’ only will and desire was to roll stone, then Sisyphus would perhaps take enjoyment in his task. This change in his perception does not change his task at hand; it only changes his perspective. His is still condemned to an eternity of meaningless and pointless labor. Therefore the existence of Sisyphus is meaningless, the labor that he performs leads him nowhere, and everything that he does is in vain. The world would be the same with or without his presence. The next section deals with the meaningless of life, he begins this section by explaining what meaningless and meaningfulness is: â€Å"Meaningless is essentially endless pointless and meaningfulness is therefore the opposite. †(Taylor, Richard) for this section he cites ugly blind worms in a New Zealand cave. These worms have the soul purpose of waiting, feeding, transforming into winged adults only living a day or two, mating, laying eggs and finally dying. This example shows us the meaning of life, an endless cycle that accumulates to nothing, and the â€Å"point of living is evidently nothing but life itself. † (Taylor, Richard) We as humans differ form this only a little. We have goals that we work for; once they are completed we set off after another goal, all this work goes to family and home, only to beget others who will follow in the same foot steps in a cycle. Even though we are stuck in a cycle of endless meaningless toil we look to religion, universal justice, brotherhood or any sort of ever lasting good that we may aim for. The last part of this excerpt is the â€Å"meaning of life† we return to the story of Sisyphus who in this example has completed his beautiful tower and is now faced with eternal boredom, before he was faced with the nightmare of pointless activity now he is faced with the hell of eternal absence and boredom. This leads into his explanation that the meaning to our lives is â€Å"our own wills, our deep interest is what we find ourselves doing†(Taylor, Richard). Even though our existence is short and our toils fade we can hold memories of the past. The point of living is to continue what we are doing because giving up and doing nothing would be no salvation. The resolution to this excerpt is that we live life because our will is to live and build castles for our children so they can build castles for theirs. This question of living has puzzled philosophers for centuries, I have also come across this question, with my reasoning I could not figure it out, for if, great philosophers couldn’t then how could I? Mr. Taylor’s views are interesting and some of what he says does make sense. The myth of Sisyphus is the focal point of Richard Taylor’s reasoning the meaning of life; he explains Sisyphus eternal punishment in detail. Richard also gives other scenarios of Sisyphus’ task, if his labors accumulated into a beautiful tower or if he was some how made to enjoy rolling stones. I agree that in a way all ours lives are like that of Sisyphus’ toil. A cycle of endless toil, we work towards our little goals and glimpse of happiness, which are sure to fade over time. The meaningless of life is explained in the second section; Richard uses two insects to show the meaningless of life, the glow worms and the cicadas. Richard states that there is no meaning to life because it is an endless cycle of pointless and meaningless events. At the moment our goals may seem a great deal of importance in our lives but in the end all our toils are pointless and meaningless in the end. I understand this point in his explanation but I disagree, I think a person can find meaning in every ting they do. It is true that this meaning doesn’t last forever but the pleasure we take from everyday life and experience is well worth it. I don’t believe that everything is meaningless in life just because we all die in the end. I believe that it’s not the end of ones life that is important; it’s the journey that one takes through life. It is the accumulation of everyday happiness that makes our lives worthwhile. There is an old saying that the end of a journey is not important, it is the lessons we learn along the journey that counts. In the last section of the excerpt is the meaning of life, Richards explains that we live life because of our own will. I also agree with this, living life with a purpose and a will is much better compared to living a life of doing nothing and boredom because we know it eventually ends. I have very optimistic views of human life; I believe that everyone’s life has a meaning and a purpose. If a person is dying of cancer and has only a few months left, but a doctor performs an operation and saves him, he will have meaning to live again and he will cherish the rest of his life, sure he will die eventually but presently he will be grateful to live and he will give the doctor a reason to continue what he is doing. In my opinion the reason we live is for experience, we live to learn and experience new things. Like that old saying about the journey and the end, it is the process of the journey that is important. We live life not thinking about our deaths, we live it for the experiences that each day brings.

Leon Walras essays

Leon Walras essays What is the role of money in Walras' general equilibrium and what determines the demand for it? Leon Walras is considered by many as the founder of the modern theory of general economic equilibrium. Money and its valuation is an important element in his Elements of Pure Economics of 1874. Money can be defined most basically as one type of circulating capital; the other is circulating physical capital. In this short essay, both the role of money in Walras' general equilibrium and how the demand for money is determined will be treated. Walras asserted that circulating physical capital yields utility according to its service of availability, that is, to the degree that it is readily available. Money likewise provides a service of availability as the commodity that physical capital is destined to purchase, and it yields the same amount of utility as physical capital. The service of availability that money provides and consequently its utility is, in my opinion, the essence of Walras' theory of money. Although he assigned other roles to the use of money as a medium of exchange and as an element of production for entrepreneurs, these roles are encompassed by service of availability. By yielding services of availability, money does improve utility and therefore must be placed in the consumer's utility function. Walras treated money as analogous to capital. Capital, he recognized, is not a regular commodity. It is not desired for itself, but is rather a facilitator of 'intertemporal' production and thus allocation. It is demanded insofar as it provides this service. [Capital goods] are demanded because of the land-services, labour and capital-services they render, or better, because of the rent, wages and interest which these services yield (267). Similarly, money is not desired for itself. It rather provides a stream of services in the form of overcoming transaction costs or permitting the temporal break-up of purchases and sale...

The University of Pennsylvania Essay Example | Topics and Well Written Essays - 1000 words

The University of Pennsylvania - Essay Example I also respect the University of Pennsylvania’s philosophy in education which is concerned with the preparation of dental students in many roles of dental practitioners such as; â€Å"scientist, clinician, artist, teacher, engineer, and business manager.† I believe this philosophy will allow me to receive an all encompassing education in dentistry which will provide me with the background needed to succeed in dentistry and achieve my goals as a health professional. The wide network of the institution reflects its commitment to reach and provide a quality health care to the surrounding community at large as well as provide an opportunity to the students to be compassionate with the patients, develop leadership skills and professionalism while at the same time building up creativity and love in a just way. It serves as a center for training students to become outstanding dentists who can influence the community with goodwill, passion and commitment.The institution also em braces and encourages an environment of discovery and promotes a global view of dentistry which is increasingly important for dental practitioners. Since the 21st century, there have been various technical developments in every field and the dentistry field has also benefitted from this advancement in technology. The students at this institution are given the opportunity of doing research and the results of various researches have helped America to be a force to reckon with in giving good oral health to its citizens.

Business Ethics and Virtue Ethics 3 SLP Essay Example | Topics and Well Written Essays - 750 words

Business Ethics and Virtue Ethics 3 SLP - Essay Example It is also seen in the fair representation of divergent views by respecting both merits and demerits. It encompasses such aspects as impartiality, fidelity and equity. Justice can always be viewed in various dimensions. In the context of harmony, justice refers to receiving an equivalent share depending on the efforts we place on an undertaking. In this respect justice is seen as a way of mitigating any misunderstanding that might arise out of inappropriate allocations. In another respect, justice emerges as a divine command that drives the conduct of humanity (Jost & Wuerth, 2011). For instance, killing somebody is wrong and should therefore be punished. It is therefore one of the moral principles that is normally intended to enhance peace and coexistence in the world. In virtue ethics, justice in this respect is quite important as a way of promoting the highest morals and principles (Gavai, 2010). In essence all the theories of justice advocate the fact that everyone should actuall y receive what they deserve in life. For instance things like wealth and social status should always be distributed in a way that matches the respective merits of individuals. More importantly, the distribution of wealth should always match the overall contribution of an individual to the social good (Hooft, 2006). The concept of justice is normally closely associated with an element of fairness in dealings. It connotes the impartial distribution of resources in a way that limits any cases of dissatisfaction. In this regard, everyone should have the liberty to enjoy all the basic rights accorded to humanity. Kindness is also one of the most important aspects in virtue ethics and refers to the condition of being kind and characterized by charitable and good behavior (Michalos, 2011). It is also seen as a way of showing concern and disposition for others. While kindness is essentially a virtue, it is normally recognized as a value in the context of religions and cultures. In any case, acts of kindness normally benefit both the receivers and the givers. To the giver, it is more about feeling a sense of contentment and relaxation out of doing well to others (Hendry, 2004). In most cases kindness is seen as the ability and willingness of helping someone in need not in return for anything. The basic concept here is the need to help the other person. Kindness as a virtue is certainly very important in all aspects of life. The element of being kind can greatly enable somebody to achieve a lot of respect and mileage in many situations. In this case, kindness is always encouraged in most cultures and religions as a ways of enhancing peace, harmony and coexistence among the various societies and communities in the world (Crisp & Slote, 2004). Honesty is also part of the moral character that is normally encouraged and highly regarded in life. The aspect of being honest connotes the attributes of integrity and truthfulness as opposed to deceit and telling lies. In this cas e, honesty encompasses straightforwardness without such aspects like theft or cheating. It is a way of encouraging people to always tell the truth since it is one of the ways of avoiding many vices in life. In an organizational setup, the element of virtue ethics is certainly very important in promoting business ethics and enhancing the proper coordination of

ENG Essay Example | Topics and Well Written Essays - 750 words

ENG - Essay Example A speech community can also develop from sharing lifestyles, hobbies and interests. People are often members of more than one speech community as they traverse from childhood to adulthood. Multiplexity is a degree of the types of relationships among members in a community. It is an important aspect of speech communities derivative from observing the ways in which persons are related. Each of these communities has their identity, culture, rules of membership that an individual has to adapt to. This essay seeks to identify a person’s journey across and between speech communities from childhood to adulthood. At childhood, a child is born to a speech community, the family. It is the basic speech community that the child has to adapt to their rules of membership, language and cultures. The family members share a language pattern that the child must adapt to. From the brothers, sisters and parents a child develops this language. The child grows up learning the language pattern the f amily members teaches them. The family dictates the speech norms, and as a child, the individual grows knowing that this is the language pattern they have to follow. The network strength in this community is based on family ties. The strength is strong since the family has a close-knit nature. The family has a low multiplexity level since it includes members with bloodily ties. After the family, the child starts attending school. At this stage, the child witnesses many speech communities. This depends on their characters and the activities they participate in school. In class, there exists a speech community between the teacher, the pupil and fellow pupils. In this community, the members use a formal language pattern with simple vocabularies. The members also have formal ties that relate to the curricular. This speech community has a specific language pattern that all the members have to adhere to. The density of the network strength is loose between the pupils and the teacher. Howe ver, between the students, they share a strong network density. Multiplexity level in this community is regular in the sense that the teacher may be one of the pupil’s parent and a relative to a fellow student. At school, the individual develops a friendship with peers either in class or during extracurricular activities. This friendship is based on sharing a common interest and hobbies. The friendship develops into a speech community where a group of friends shares the same language pattern. The social network in this community is dense since the members share ideas and interactions at a regular basis (Wardhaugh 120). Multiplexity is also common since, in this friendship circles, the members can be related. In this community, there exists a speech norm that each member enjoys and understands. Although the members differ in personal characteristics, they share the same hobbies and interest. For instance, it is common that members of this speech share the same genre of music. This community can be from adolescence to early teenhood. From teen hood to adulthood, the individual meets up a new speech community. This is usually in institutions of higher learning. The first speech community is in class depending on the course the person is studying. This speech community is different from junior and senior school. At this stage, the vocabulary is complex, and the language is very formal. There exists a mutual relationship between the lecture or professors and

Why Governments Regulate The Health Care Industry Economics Essay

Why Governments Regulate The Health Care Industry Economics Essay In the first part of the essay we define market failure and look at the model of perfect market, we then compare this with health care market and find out the causes or factors that results in failure in the health care market. In the second part we will look at the ways governments in four different countries have intervened to ensure that the causes of the market failure are corrected. Market failure can defined as a situation whereby there is a failure to achieve an efficient allocation of resources within the market economy. A fundamental problem with the concept of market failure, as economists occasionally recognize, is that it describes a situation that exists everywhere (Nelson, 1987; Dahlman, 1979). There are different kinds of market that exist in the society with the perfect market and monopoly at the extremes and the others in between this spectrum. Perfect Market The perfect market model also referred to as a perfect competition is the most important model because it serves a benchmark from which other kinds of market can be viewed. The main objective of any firm in the market is to maximise profit and the price of the goods and services are determined by market forces. The perfect market is based on the following assumptions; There is full information, The transactions are impersonal, There are no barriers to entry or exit, There are many buyer and sellers, and they cannot influence the market price, The products are homogenous which means that the buyers cannot differentiate between products. Finally the goods are private goods. Why is health care market different? The first reason for this is that health care is a public good which is different from a private good as seen in the perfect market model, public good has two features, non-rivalrous which means that the use of it by one person does not stop another from benefitting from it, and it is non-excludable this means it will difficult to prevent people from enjoying the benefits. With public good there is what is known as a free-rider problem people will not pay for them because others are willing to pay for them. The nature of public goods poses a problem for the market because the private sector will not make a profit from their provision since everyone can enjoy it whether they pay or not. Health care is also a public good and under provision of it also leads to market failure. Health care is also a merit good that society values and believes that people should have them because consumption is believed to generate positive externalities-this will be discussed in the next paragraph as we ll as other causes of market failure. Causes of market failure in health care 1. Externalities Externalities also referred to as third-party effects occur when others are affected by the transaction arising from the production and consumption of health care for which the costs or benefits are not taken into account.The core of the argument against market failure analysis is derived from the study of transactions. (Zerbe et al p7).Whenever there is a transaction externalities are known to occur which leads to transaction costs. This is defined as the resources necessary to transfer, establish and maintain property rights. The property rights was developed by R H Coase where he stated that individuals form firms to reduce transaction costs. Externalities may arise in different ways and they may be either positive (beneficial) or negative (harmful), and can be during production or consumption. Examples of negative externality is smoking which results in external costs on a third party passive smoking and also alcohol ingestion can lead to antisocial behaviour. Vaccination agains t infectious diseases is a form of positive externality where an individual is certain of protection by the consumption of another person. An example of external cost of production is via pollution from an industry and external benefits of production is the patent rights given to firm that discovered a new drug, stopping all other firms from copying the products. When there are externalities in health care this will not lead to a perfect market hence market failure will occur. The externalities discussed so far can be referred to as selfishly motivated. There is externality referred to as caring externality which occurs when individuals get personal satisfaction from knowing that a person is getting the health care they need. Externalities are around us every day but they are not taken into account whenever there is a transaction, this is because property rights are not well defined. Health care is not owned by anyone so therefore there is economic incentive to protect it and the on ly way the property rights can be well defined and protected will be through government regulation e.g. by banning smoking in public places and also making vaccinations compulsory. Even with government legislation it is difficult to achieve this. (Zerbe,1976,1980;Medema and Zerbe,1999a),in a world in which property rights are fully specified and in which transaction costs are zero, the allocation of resources will be efficient. This kind of world does not exist, this is an indication that market failure will always occur. 2. Imperfect information Economics is concerned with the efficient use of limited productive resources for the purpose of attaining the maximum satisfaction of our material wants (Jackson and McConnell, 1985, p3), this involves transacting parties utilising these resources to meet and satisfy their wants. This is based on the assumption that the parties have full information about the goods and services being bought or sold and also about each other. These assumptions describe a market where there is perfect information (Stiglitz, 1993).In the health care there is imperfect information and/or information asymmetry. Information asymmetry can be defined (using the acquisition of health insurance as a classical example) as situation whereby client that wants to get a health insurance has more detailed information about himself than the insurance company. Imperfect information is the case of a physician who has more knowledge than patients. The uncertainty of illness and the cost of it when it arises is one the principal reasons for taking health insurance. Two problems arise whenever there is insurance cover; these are adverse selection and moral hazard. Information asymmetry and adverse selection was first described by George Akerlof in his article, The market for lemons: Quality, Uncertainty and the Market Mechanism. Adverse selection is often referred to as a hidden information problem in a market, where for example sellers may know more about a product than a customer. (Estrin and Laidler). During the 1980s, when HIV/AIDS was first discovered insurance companies suffered from adverse selection as a lot on individuals with this disease took increased insurance cover without disclosing their status. This led to the suggestion that genetic testing should be used for individuals who may wish to acquire health insurance.The concept moral hazard was first defined by the French economist Dreze in 1961 (Mooney 1994, p 135), but it is often described as a hidden action because it results in be havioural changes in patients once their expected losses are covered by health insurance. Ehrlich and Becker (1972) distinguished between ex ante and ex post moral hazard. The former occur in a healthy state when individuals can engage in preventive care such as regular exercises and good eating habits and the latter when the individual is ill, but since the health be it taxation or other forms of health insurance which allows a subsidise price or free at the point of use, there is a greater demand by the patient than it will be if the patient was to pay all the costs. Donaldson and Gerard (1993, p 31), comments,thus, the market fails to transmit efficient price signals to consumers. Donaldson and Gerrard (1993) identified two types of provider moral hazard. They identify moral hazard by doctors who are identifiable actors in the health care system and also moral hazard by hospitals. Doctors are known to act on behalf of the patients both as the demander and supplier of services and do not account for the cost. First on the supply side they are the provider of health care and on the demand side there is information asymmetry. There are different reimbursement which affects doctors attitudes and two that affects the patients attitudes ( charges to patients, private practice).Provider moral hazard occurs most commonly with the fee-for-service (FFS) reimbursement doctors are paid on the quantity of services; more services will result in a higher income. Therefore there is a financial incentive for physicians to provide care in excess of what the patients may require if they had full information. There is not much literature on hospital moral hazard so this can be a n area for future development. 3. Imperfect competition The perfect market provide the best means of making sure that the economy is efficient by encouraging firms to compete and also creating choice. These conditions for efficiency serve as a benchmark to help identify sources of allocative inefficiency referred to as market failures. But in the real world the perfect market does not exist as Hausman argued, when taken literally, the notion of market failure is of little relevance, because perfectly competitive equilibrium, the benchmark against which market fail, does not obtain. Despite this the competitive market have been used on the assumptions on which it was formed, as Amelia Fletcher, Director of Markets and Policies Initiatives commented, Competition is a rivalrous process, in which firms compete effectively to give the consumers a better deal. The question is that is this obtainable in health care with the uncertainty that surrounds ill health? The first problem here is the limited information has about the outcomes and benefit s of various medical treatments. Individuals rarely have the same illness over time so there is little opportunity to acquire information and even on those with long standing chronic illness like diabetes who may have information. The changing world of advanced technologies means that there will be information disparities. Oligopoly is the dominant market model in health care and McPake and Normand (2008, p 141) noted, the key feature of an oligopoly is that the decision made by one firm depends on the decision made by other firms, i.e. there is a high degree of interdependence between firms. Thus there may be incentives for hospitals to collude which results in adverse outcomes for the society. It is generally accepted that competition works best when there is excess capacity, but in health care there is excess demand. 4. Inequality and poverty An individual ability to purchase health care depends upon his income to a large extent. In standard economic theory its the ability and willingness to pay that determines how resources are maximally utilised but this does not happen in the real world as we have noted from previous sections in this essay. Goodwin (2005) commented that, hospitals make demand and other raw materials from suppliers with the expectation that the final products will be bought by consumers-the demand by consumers are those backed by the consumers ability to pay. So what is important in a perfect market is effective demand i.e., there is distribution of resources to meet the basic human needs. Therefore if for example few wealthy people desire a particular commodity and many poor people lack money to purchase basic health needs then the market will be stimulated to create those commodities for the rich, hence the market will fail. Government intervention and regulation of health care market From our discussion it can be seen that intervention is necessary to counteract the causes of market failure as well as the consequences such as adverse selection and moral hazard. Boadway and Wildasin (1984, p 61) suggest that, while typically the remedy for market failure due to public goods is for the public sector to provide the good, the remedy for externalities is often to provide incentives to the private sector to produce the correct amount. We will examined detailed evidence from four countries: the United Kingdom (UK), the United States of America (USA),France and Finland to ascertain how they intervene and regulate their health care systems. Methods of government intervention 1. State provision One of the main ways of solving market failure is through public funding of the health service. In the UK, France and Finland hospitals are funded through taxes but in UK it is through general taxation while France and Finland use a social insurance system. This system ensures universal coverage for the population, prevents exploitation of patients by monopoly of providers. The main problem is the issue moral hazard which is more common in publicly tax funded system in UK than the social insurance system of Finland and France. In the UK the issue of moral hazard is controlled by using gatekeepers, waiting lists, waiting times. In France and Finland price mechanism is used to deter moral hazard. Compared to the USA where it is more of private insurance, co-payments, deductibles and medical savings account schemes have been used as ways of reducing moral hazard. Donaldson and Gerard (1993, p 72) argued that, even the US health care system recognises the shortcomings of a total reliance upon market forces. The main form of government regulation there is in the form of insurance schemes for elderly people (Medicare) and indigent people (Medicaid). But in the USA, adverse selection is very common and it also occurs in UK but to a lesser extent, but this is almost non-existent in the social insurance system (France and Finland). 2. Taxation and subsidies Imperfections in the market lead to inefficient allocation of resources and this leads to negative or positive externalities. Taxation is used to discourage certain behaviours like monopolising and overpricing and subsidies can help to reduce the cost of paying for merit goods like health care. Governments in all four countries for example in order to reduce the negative externalities caused by smoking introduced taxes for the purchase for cigarettes and also legislate that companies should advertise the dangers of smoking on the pack of cigarettes sold.Antirust legislation are passed in all four countries e.g. law prohibiting the formation of monopolies and preventing imperfect competition. 3. Regulation Dolan and Olsen (2002), commented that there is constant pressure for more spending in most health services around the world, therefore policy makers have to impose regulatory measures on the providers of services to achieve efficient allocation of the resources. Regulation can be through price control, quality control e.t.c. Regulation of pharmaceuticals is one area where most of government intervention occur, for example in the UK, the National Institute of Clinical Excellence(NICE) issues guidelines on which drugs are approved and can also be used. Also sets a ceiling on how much the cost should be but one main disadvantage is that it can exclude the use of new and effective treatment because of the costs. In USA there is the Food and Drug Administration (FDA) which also a regulatory body. In France there is the Agence Francaise de Securite Sanitaire des Produits de Sante (AFSSAPS), and in Finland the National Agency for Medicines. 4. Cost benefit analysis Government intervention must take into account the cost benefit analysis, if the benefits are more than the costs. Then the government should collect taxes and provide the good. Government failure Government failure can occur when mechanisms put in place to improve the market failure worsens the situation and lead to inefficiency and inequity in the health care and also create distortion. The following can result in government failure; 1. Inefficiency of State provision In all four countries political self interest can lead to inefficiency and worsen the market failure already present because politicians can design policies to retain power rather than maximise efficiency. In France and Finland the taxation is usually higher and results in more expenditure and in the UK the citizens do not know how much is been used for health care and other sectors of the economy. 2. Changes in government policies In the USA insurance firms can find it difficult to plan without knowledge of taxes, subsidies e.t.c and this will lead to inefficiency. 3.Free markets usually leads to more efficient provision of health care(USA as an example) which allows the law of demand and supply to determine how the market works 4. Lack of incentives Undesirable incentives usually create inefficiencies, for example in France where doctors are paid by salary in some hospitals this will lead to inefficiency. 5. Lack of information Government can lack information just as much as the market because most times the government do not know what kind of health care the consumer really needs and provides this based on the information they have and may not even know the full costs/benefits of the policy. 6. Bureaucracy Most times procedures of the government are usually cumbersome and this cuts across all the four countries. Governments respond more slowly to changes and also the time it takes from planning to implementation may cause policies to be ineffective. Conclusion Market failure is known to exist in all market economy and the health market is not an exception. It has been shown that there reasons why health care market may not work efficiently, thereby necessitating government intervention. Health care is a public good and coupled with the externalities and information gaps are causes of market failure which requires correction but a sufficient justification for government intervention. Intervention is known to be costly, so therefore for it to be effective a cost-benefit analysis to suggest it is worthwhile needs to undertaken to avoid government failure which lead to market failure in itself.